Stability of Solid Dosage Forms. II. Coloration and Photolytic Degradation of Sulfisomidine Tablets by Exaggerated Ultraviolet Irradiation
スポンサーリンク
概要
- 論文の詳細を見る
The solid-state stability of sulfisomidine tablet under the irradiation of ultraviolet rays, was investigated colorimetrically and spectrophotometrically. The coloration of tablet surface was followed in the Lab system in the fade-o-meter. In order to examine the effect of ultraviolet intensity on the rate of coloration and photolytic degradation, a series of glass color filters which shut off the ultraviolet rays in order, were employed. The coloration was found to best fit an apparent second-order degradation equation with respect to colorimetric values. Photolytic degradation was investigated by the semi-integral attenuance spectra in the ultraviolet region. It proceeded following the apparent zero-order kinetics which accompany an induction period. The ultraviolet intensity affected the kinetic constants as well as in the coloration. These degradation behaviors in the solid state were compared with the aqueous solution state.
- 公益社団法人日本薬学会の論文
- 1976-09-25
著者
-
松田 芳久
Kobe Pharmaceutical University
-
松田 芳久
Kobe Women's College Of Pharmacy
-
南田 祐子
Kobe Women's College of Pharmacy
-
南田 祐子
Kobe Women's College Of Pharmacy
関連論文
- Dissolution Behavior of Piretanide Polymorphs at Various Temperatures and pHs
- NEW SKELETAL DRUG DELIVERY SYSTEM CONTAINING ANTIBIOTICS USING SELF-SETTING BIOACTIVE GLASS CEMENT
- Kinetic Study on the Isothermal Transition of Benoxaprofen Polymorphs in the Solid State at High Temperature
- Physico-chemical Properties and Isothermal Transition of Acetazolamide Polymorphs
- Effect of CO_2 Laser Irradiation on the Surface Hardness of Self-Setting Hydroxyapatite Cement
- Preparation of Piretanide Polymorphs and Their Physicochemical Properties and Dissolution Behaviors
- Photostability of Indomethacin in Model Gelatin Capsules : Effects of Film Thickness and Concentration of Titanium Dioxide on the Coloration and Photolytic Degradation
- Coloration and Photolytic Degradation of Some Sulfonamide Tablets under Exaggerated and Ordinary Ultraviolet Irradiation
- DISSOLUTION BEHAVIOR OF PHENYTOIN-BILE SALT COMPLEXES PREPARED BY CO-GRINDING
- PARTICLE SIZE EFFECT OF METASTABLE CALCIUM PHOSPHATES ON CRUSHING STRENGTH OF SELF-SETTING BIOACTIVE CALCIUM PHOSPHATE CEMENT
- Physicochemical Properties of Nitrofuratoin Anhydrate and Monohydrate and Their Dissolution
- EFFECT OF LASER IRRADIATION ON SURFACE HARDNESS OF SELF-SETTING HYDROXYAPATITE CEMENT
- A NOVEL SKELETAL DRUG DELIVERY SYSTEM FOR ANTI-BACTERIAL DRUGS USING SELF-SETTING HYDROXYAPATITE CEMENT
- CHARACTERIZATION OF NITROFURANTION ANHYDRATE AND MONOHYDRATE, AND THEIR DISSOLUTION BEHAVIORS
- A Kinetic Study on the Isothermal Transition of Polymorphic Forms of Tolbutamide and Mefenamic Acid in the Solid State at High Temperatures
- Physicochemical Characterization of Oxyphenbutazone and Solid-State Stability of Its Amorphous Form under Various Temperature and Humidity Conditions
- Stability of Solid Dosage Forms. II. Coloration and Photolytic Degradation of Sulfisomidine Tablets by Exaggerated Ultraviolet Irradiation