Coloration and Photolytic Degradation of Some Sulfonamide Tablets under Exaggerated and Ordinary Ultraviolet Irradiation
スポンサーリンク
概要
- 論文の詳細を見る
Five sulfonamide tablets, those of sulfaphenazole, sulfadimethoxine, sulfisomidine, sulfisoxazole, and sulfamethizole, were exposed to exaggerated and ordinary ultraviolet (UV) rays for stability studies in the solid state, and the relationship between coloration stability and chemical degradation was investigated. The color change of tablet surface was measured by colorimetric method. Sulfisoxazole and sulfamethizole were photostable in coloration, and sulfadimethoxine was eventually not colored contrary to what was stated in the Pharmacopeia of Japan. Photosensitive similarity between exaggerated and ordinary exposure was not established in coloration. Photolytic degradation was examined spectrophotometrically and crystallographically. Interesting absorption changes were observed in UV spectra, whereas no apparent changes in either infrared spectra or X-ray diffraction patterns. These evidences were discussed in relation to the results obtained by the complementary tristimulus colorimetry using the UV absorption data. For all the sulfonamides, evident correlation did not exist between coloration and photolytic degradation.
- 公益社団法人日本薬学会の論文
- 1978-09-25
著者
-
松田 芳久
Kobe Pharmaceutical University
-
松田 芳久
Kobe Women's College Of Pharmacy
-
三原 真理
Kobe Women's College of Pharmacy
-
三原 真理
Kobe Women's College Of Pharmacy
関連論文
- Dissolution Behavior of Piretanide Polymorphs at Various Temperatures and pHs
- NEW SKELETAL DRUG DELIVERY SYSTEM CONTAINING ANTIBIOTICS USING SELF-SETTING BIOACTIVE GLASS CEMENT
- Kinetic Study on the Isothermal Transition of Benoxaprofen Polymorphs in the Solid State at High Temperature
- Physico-chemical Properties and Isothermal Transition of Acetazolamide Polymorphs
- Formation of 4-Formylaminoantipyrine as a New Metabolite of Aminopyrine. II. Enzymatic Demethylation and Oxidation of Aminopyrine and 4-Monomethylaminoantipyrine
- Effect of CO_2 Laser Irradiation on the Surface Hardness of Self-Setting Hydroxyapatite Cement
- Preparation of Piretanide Polymorphs and Their Physicochemical Properties and Dissolution Behaviors
- Photostability of Indomethacin in Model Gelatin Capsules : Effects of Film Thickness and Concentration of Titanium Dioxide on the Coloration and Photolytic Degradation
- Coloration and Photolytic Degradation of Some Sulfonamide Tablets under Exaggerated and Ordinary Ultraviolet Irradiation
- DISSOLUTION BEHAVIOR OF PHENYTOIN-BILE SALT COMPLEXES PREPARED BY CO-GRINDING
- PARTICLE SIZE EFFECT OF METASTABLE CALCIUM PHOSPHATES ON CRUSHING STRENGTH OF SELF-SETTING BIOACTIVE CALCIUM PHOSPHATE CEMENT
- Physicochemical Properties of Nitrofuratoin Anhydrate and Monohydrate and Their Dissolution
- EFFECT OF LASER IRRADIATION ON SURFACE HARDNESS OF SELF-SETTING HYDROXYAPATITE CEMENT
- A NOVEL SKELETAL DRUG DELIVERY SYSTEM FOR ANTI-BACTERIAL DRUGS USING SELF-SETTING HYDROXYAPATITE CEMENT
- CHARACTERIZATION OF NITROFURANTION ANHYDRATE AND MONOHYDRATE, AND THEIR DISSOLUTION BEHAVIORS
- A Kinetic Study on the Isothermal Transition of Polymorphic Forms of Tolbutamide and Mefenamic Acid in the Solid State at High Temperatures
- Physicochemical Characterization of Oxyphenbutazone and Solid-State Stability of Its Amorphous Form under Various Temperature and Humidity Conditions
- Stability of Solid Dosage Forms. II. Coloration and Photolytic Degradation of Sulfisomidine Tablets by Exaggerated Ultraviolet Irradiation