Microbial Metabolism of N-Methylcarbamate Insecticide. III. Time Course in Metabolism of o-sec-Butylphenyl N-Methylcarbamate by Aspergillus niger and Species Differences among Soil Fungi

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The biotransformation, time dependent changes of metabolites and differences of the mode of metabolism among five fungi, which were all isolated from the soil of rice field treated with o-sec-buthylpenyl N-methylcarbamate (BPMC) (I) were investigated using ^3H-BPMC. In every fungus used in the present study, a common metabolic pathway was that through hydroxylation at the alkyl side-chain. The metabolic breakdown of I by A. niger reached the maximum at 2 or 3 days cultivation and hydroxylation at alkyl side-chain of I was attained at the early stage of cultivation. Remarkable differences have been shown to exist among the various species as to formation of metabolites.
社団法人日本薬学会の論文
1976-09-25