Effect of Surface-active Agent on the Active Transport of Sodium in Frog Skin

概要

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The effect of surface-active agent on the active transport of sodium in the frog skin was studied. It was assumed that alkyldimethylbenzylammonium chloride (alkyl-DBAC) in 10^<-3>M concentration inhibited the active transport of sodium accompanied with Na^+-K^+ adenosine triphosphatase (ATP ase), whereas it increased the influx and outflux of ^<34>Na through the frog skin probably due to the structural damage on the frog skin. This effect was observed above the critical micellar concentration of this surfactant. The increased influx of ^<24>Na was decreased by the addition of 1 μg Pi/ml of phospholipid to 10^<-3>M alkyl-DBAC, but it still remained at a higher level. The effect of phospholipase C on the active transport of sodium in the frog skin was different from that of alkyl-DBAC, and 0.5 mg/ml of phospholipase C also increased the influx of ^<24>Na, whereas the increased influx of ^<24>Na was depressed by 10^<-5>M ouabain.
社団法人日本薬学会の論文
1976-02-25