Studies on LM Protein Appearing in Submandibular Glands of Isoproterenol-treated Rats. I. Purification and Characteristics of Its Appearance

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A large mobile (LM) protein that is accumulated in saliva of rats upon chronic administration of isoproterenol (IPR), a β-adrenergic drug (L. Menaker, et al., Ala. J. Med. Sci., 11,356-358 (1974)), has been purified to electrophoretic homogeneity. Rabbit anti-LM protein antibody was prepared, and used for determination of the LM protein by a single radial immunodiffusion method. The increase in the amount of this protein in the soluble fraction of submandibular glands was roughly proportional to the increase in the wet weight of glands and the most effective dose of IPR was found to be 40 mg/kg. The LM protein which accumulated in the submandibular glands upon chronic administration of IPR was secreted as a result of IPR stimulation, whereas methoxamine, an α-adrenergic drug, did not induce significant secretion of the accumulated LM protein. Apparently the protein newly synthesized in submandibular glands upon chronic administration of IPR is secreted through the action of β-adrenergic receptors.
公益社団法人日本薬学会の論文
1981-05-23