Studies on the Oxidation of "Reversed Nucleosides" in Oxygen. III. Synthesis of Eritadenine Analogues of Purines and Pyrimidines

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概要

• 論文の詳細を見る

• Reaction of methyl 5-O-tosyl-2,3-O-isopropylidene-β-D-ribofuranoside (1) with the sodium salts of purines, (2) and (3), and pyrimidines, (12), (13), and (14) derivatives in DMF afforded the corresponding "reversed nucleosides". 6-Alkylaminopurine analogues were prepared by the reaction of the 6-methylthiopurine derivative (4) with the amines. After removal of the protective groups, the reversed nucleosides were oxidized by oxygen in dilute alkaline solution to afford easily eritadenine analogues as major products.

• 公益社団法人日本薬学会の論文
• 1974-12-25

著者

• 菅野 毅

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 河津 光高

  Organic Chemistry Research Laboratory of Tanabe Seiyaku Co., Ltd.

• 河津 光高

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

関連論文

• Studies on the Synthesis of Some Pyrrolocoumarins and Furoquinolones
• Studies on the Oxidation of "Reversed Nucleosides" in Oxygen. IV. Synthesis of 4-(6-Aminopurin-9H-9-yl)-3(R)-hydroxy-2(R)-aminobutyric Acid
• Studies on the Oxidation of "Reversed Nucleosides" in Oxygen. III. Synthesis of Eritadenine Analogues of Purines and Pyrimidines

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