Studies on the Metabolism of Oxazolam. II. Isolation and Identification of the Metabolites of Oxazolam in Rats

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概要

• 論文の詳細を見る

• ^14C-Oxazolam (10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenylbenzo [6,7]-1,4-diazepino [5,4-b]-oxazol-6-one), randomly labeled with ^14C in the 11b-phenyl ring, was administered orally to the rat, and a number of metabolites were detected in the extracts of liver, kidney, brain, blood, urine and feces by thin-layer chromatography. Among those metabolites, N-desmethyl diazepam, oxazepam and 2-(2-hydroxy-n-propylamino)-acetylamino-5-chlorobenzophenone (PACB) were isolated from the liver extracts, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-2H-1,4-benzodiazepine-2-on (CDHB) from the bile, and 2-amino-5-chlorobenzophenone (ACB), 2-amino-5-chloro-3-hydroxybenzophenone (ACHB) and ACHB glucuronide from the urine. On the basis of these findings, a possible metabolic pathway of oxazolam was discussed.

• 公益社団法人日本薬学会の論文
• 1971-09-25

著者

• 服部 健二

  Central Research Laboratories Sankyo Co. Ltd.

• 村田 寿

  Central Research Laboratories, Sankyo Co., Ltd.

• 村田 寿

  Central Research Laboratories Sankyo Co. Ltd.

• 安村 明

  Central Research Laboratories and Product Development Laboratories, Sankyo Co., Ltd.

• 安村 明

  三共株式会社中央研究所

• 松田 啓一

  Central Research Laboratories, Sankyo Co., Ltd.

• 松田 啓一

  Central Research Laboratories Sankyo Co. Ltd.

関連論文

• Distribution and Excretion of Benhepazone administered to Rats.
• Studies on the Metabolism of Oxazolam. I. Distribution and Excretion Studies
• 14-Hydroxydihydro-6β-thebainol 4-Methylether(Oxymethebanol)の吸収, 分布, 排泄ならびに代謝
• チトクロムcヘムオクタペプチド(CHP)の代謝 その1 ^3H-CHP, ^S-CHPの作成とラット投与における吸収, 分布, 排泄, およびマウスにおけるオートラジオグラフィー
• A Fluorometric Method for the Estimation of Benhepazone.
• Studies on the Metabolism of Oxazolam. II. Isolation and Identification of the Metabolites of Oxazolam in Rats
• Metabolism of Cloxazolam. I. Distribution, Excretion and Biotransformation in Rats and Mice

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