Studies on an Antibiotic, Albocycline. IV. Catalytic Hydrogenation and Structure Elucidation of Albocycline

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概要

• 論文の詳細を見る

• By the catalytic hydrogenation of albocycline at room temperature four hydrogenation products were obtained. Two of them, II and III, were confirmed to have 14-membered lactone and 5-membered lactone structure respectively from infrared (IR) and nuclear magnetic resonance (NMR) spectral data. They were the isomer and correlated to each other. These correlations suggested the position of a hydroxy group in albocycline. II was derived to the corresponding hydrocarbons (IV) by complete hydrogenation, of which mass spectra suggested the carbon skeleton and branching pattern of methyl group. From these results and the 100 MHz NMR spectral data of albocycline and its acetate, the structure of albocycline was finally proposed as Ia.

• 公益社団法人日本薬学会の論文
• 1971-04-25

著者

• 鈴木 真言

  Microbial Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 長浜 昇

  Microbial Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 高森 勲

  Microbial Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 長浜 昇

  Microbial Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 高森 勲

  Microbial Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

関連論文

• Studies on an Antibiotic, Albocycline. III. Partial Structure of Albocycline
• Studies on an Antibiotic, Albocycline. V. High Pressure-High Temperature Hydrogenation Products, and Structure Proof of Albocycline
• Studies on an Antibiotic, Albocycline. IV. Catalytic Hydrogenation and Structure Elucidation of Albocycline
• 6 ナルボマイシンおよびピクロマイシンの生合成

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