Chiral Pyrrolidine Derivatives as Catalysts for the Enantioselective Addition of Diethylzinc to Aldehydes

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概要

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• A chiral hydroxylated pyrrolidine derivative (4) and an N-(2-mercaptoethyl)pyrrolidine derivative (1c) were synthesized from D-ribonolactone and were used as chiral catalyst ligands in the reaction of diethylzinc and aldehydes. High asymmetric induction of up to 95% ee was observed in the addition to aromatic aldehydes using the chiral hydroxylated pyrrolidine derivative 4.

• 公益社団法人日本薬学会の論文
• 1996-03-15

著者

• Ikota Nobuo

  National Institute Of Radiological Sciences

• Inaba H

  National Institute Of Radiological Sciences

• Inaba Hiroko

  National Institute Of Radiological Sciences

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• THE USE OF OPTICALLY ACTIVE HYDROXYLATED PYRROLIDINONE DERIVATIVES IN NATURAL PRODUCT SYNTHESIS
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