Systhesis of Manool-Related Labdane Diterpenes as Platelet Aggregation Inhibitors
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概要
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Enantioselective total synthesis of the labdane diterpene (-)-1,was achieved starting from the R-(-)-enantiomer of the Wieland-Miescher ketone (3). The enantiomer (+)-1 was obtained by partial synthesis via microbial transformation of sclareol (24). These results established that the natural compound (+)-1,a platelet aggregation inhibitor, has a normal absolute stereochemistry like that of manool (2). The B-norlabdane-related compound 44 was also synthesized using a novel ring contraction reaction.
- 公益社団法人日本薬学会の論文
- 1993-10-15
著者
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北所 健悟
Shionogi Research Laboratories Shionogi & Co. Ltd.
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池西 裕二
Shionogi Research Laboratories Shionogi & Co. Ltd.
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香川 清水
Shionogi Research Laboratories
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十倉 一也
Shionogi Research Laboratories
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川田 健司
Shionogi Research Laboratories Shionogi & Co. Ltd.
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安井 健
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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安井 健
Shionogi Research Laboratories Shionogi & Co. Ltd.
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