A Study of 1 : 1 Plus 1 : 2 Complexes between Barbiturate and α-Cyclodextrin Using the Freezing Point Depression Method

概要

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The freezing point depression method for studying drug interaction has been extended to a system containing both 1 : 1 (AB) and 1 : 2 (AB_2) complexes. The osmotic concentration of dilute aqueous solutions was measured by this method with a commercially available osmometer. On the basis of the colligative properties, a mathematical model has been proposed to calculate the apparent stability constants (K_1 and K_2). This method is applied to complexes of α-cyclodextrin with three barbiturate derivatives (barbital, phenobarbital, and pentobarbital). The results showed that the apparent stability constants obtained were in fair agreement with those obtained by the spectroscopic method. The advantage of this method is that the apparent stability constant could be estimated quickly using a simple procedure.
社団法人日本薬学会の論文
1993-08-15