Adsorption Characteristics of γ-Globulin on Carboxylated Microcapsules

概要

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Poly(1,4-piperazinediylterephthaloyl) microcapsules having different degrees of carboxylation were prepared and the adsorption characteristics of bovine serum γ-globulin on these microcapsules were examined. The amount adsorbed was larger and the rate of adsorption was lower for the microcapsules of low surface negative charge than for those of high surface negative charge, and the effect of temperature upon the adsorption on the former was greater. These observations suggested the existence of differences in orientation and conformational changes of adsorbed γ-globulin depending on the surface negative charge of the microcapsules. In addition, complement was more extensively activated by γ-globulin adsorbed on the microcapsules of high surface negative charge than by that adsorbed on those of low surface negative charge, which indicates that molecular assembly of adsorbed γ-globulin is also an important determinant for biocompatibility of biomedical materials.
社団法人日本薬学会の論文
1986-02-25