Synthesis, Structure and Antitumor Activity of a New Water-Soluble Platinum Complex, (1R, 2R-Cyclohexanediamine-N, N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O^2]platinum(II)

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概要

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• The reaction of dihydroxo(1R, 2R-cyclohexanediamine)platinum(II) with 2,4-dioxopentanoic acid gave a water-soluble complex, (1R, 2R-cyclohexanediamine-N, N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O^2]platinum(II). The structure of the complex was determined by X-ray crystal analysis. The data indicated a chelation of the acetylacetonato part of 2,4-dioxo-pentanoic acid to platinum(II). The complex showed moderate antitumor activity against murine leukemia L1210 in mice (T/C=195% at a dose of 200 mg/kg) and high activity against cisplatin-resistant L1210 leukemia (T/C=275% at a dose of 25 mg/kg).

• 公益社団法人日本薬学会の論文
• 1993-02-15

著者

• 波多 剛

  Basic Research Laboratories, Toray Industries, Inc.,

• 北野 幸重

  Toray Research Center

• 河合 英樹

  Basic Research Laboratories, Toray Industries, Inc.,

• 武藤 昌図

  Basic Research Laboratories, Toray Industries, Inc.,

• 波多 剛

  Basic Research Laboratories Toray Industries Inc.

• 河合 英樹

  Basic Research Laboratories Toray Industries Inc.

• 武藤 昌図

  Basic Research Laboratories Toray Industries Inc.

関連論文

• Synthesis, Structure and Antitumor of a Water-Soluble Platinum Complex, (1R, 3R, 4R, 5R)-(-)-Quinato(1R, 2R-cyclohexanediamine)platinum(II)
• Synthesis, Structure and Antitumor Activity of a New Water-Soluble Platinum Complex, (1R, 2R-Cyclohexanediamine-N, N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O^2]platinum(II)

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