Synthesis, Structure and Antitumor of a Water-Soluble Platinum Complex, (1R, 3R, 4R, 5R)-(-)-Quinato(1R, 2R-cyclohexanediamine)platinum(II)

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概要

• 論文の詳細を見る

• The reaction of dihydroxo(1R, 2R-cyclohexanediamine)platinum(II) with (-)-quinic acid gave a water soluble complex, (-)-quinato(1R, 2R-cyclohexanediamine)platinum(II). The crystal structure of the complex was determined by X-ray analysis. The data indicate a chelation of the α-hydroxycarboxylic acid part of quinic acid to platinum(II).The complex shows moderate antitumor activity against murine leukemia L1210 at high doses (T/C×100=179% at a dose of 200mg/kg).

• 公益社団法人日本薬学会の論文
• 1992-06-25

著者

• 金子 達矢

  Basic Research Laboratories Toray Industries Inc.

• 波多 剛

  Basic Research Laboratories, Toray Industries, Inc.,

• 北野 幸重

  Toray Research Center

• 河合 英樹

  Basic Research Laboratories, Toray Industries, Inc.,

• 武藤 昌図

  Basic Research Laboratories, Toray Industries, Inc.,

• 波多 剛

  Basic Research Laboratories Toray Industries Inc.

• 河合 英樹

  Basic Research Laboratories Toray Industries Inc.

• 武藤 昌図

  Basic Research Laboratories Toray Industries Inc.

関連論文

• Synthesis, Structure and Antitumor of a Water-Soluble Platinum Complex, (1R, 3R, 4R, 5R)-(-)-Quinato(1R, 2R-cyclohexanediamine)platinum(II)
• Synthesis, Structure and Antitumor Activity of a New Water-Soluble Platinum Complex, (1R, 2R-Cyclohexanediamine-N, N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O^2]platinum(II)

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