Selected Ion Monitoring for the Determination of Bromovalerylurea in Human Plasma

概要

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A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVD quantification by this method was 2ng/0.1ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic.
公益社団法人日本薬学会の論文
1992-06-25