Determination of Gallopamil in Human Plasma by Selected Ion Monitoring

概要

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A gas chromatographic mass spectrometric procedure using selected ion monitoring is described for the quantification of gallopamil in human plasma. Gas chromatographic separation of gallopamil from phenolic metabolite isomers is made possible by treatment with ethyl chloroformate. The detection limit for the quantitation by the present method is 0.09ng/ml of plasma. The method has sufficient sensitivity to permit pharmacokinetic studies with human subjects following the oral administration of gallopamil hydrochloride.
公益社団法人日本薬学会の論文
1991-01-25