Inhibition of Endothelin (ET)-1- and ET-2-Induced Vasoconstriction by Anti-ET-1 Monoclonal Antibody
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概要
- 論文の詳細を見る
We produced a monoclonal antibody to endothelin (ET)-1,tested cross-reactivities with the related peptides by enzyme immunoassay, and invenstigated the effects of the antibody on ET-1- or ET-2-inducced vasocontriction of rat isolated thoracic aorta. The antibody recognized ET-1,ET-2 and ET-3,and the immunoreactive site proved to be the N-terminal region but not the C-terminal region of ET-1. Moreover, at an approximate molar-equivalent concentration, the antibody absorbed ET-1 and ET-2,and significantly inhibited ET-1- and ET-2-induced vasoconstriction notwithstanding the presence of the endothelin receptor.
- 社団法人日本薬学会の論文
- 1991-05-25
著者
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岡部 哲郎
The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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枝野 敏行
Tokyo Research Laboratories, Kowa Co., Ltd.
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新井 晃一
Tokyo Research Laboratories, Kowa Co., Ltd.
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古志 朋之
Tokyo Research Laboratories, Kowa Co., Ltd.
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平田 光輝
Tokyo Research Laboratories, Kowa Co., Ltd.
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大口 正夫
Tokyo Research Laboratories, Kowa Co., Ltd.
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鳥居 功博
Tokyo Research Laboratories, Kowa Co., Ltd.
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古志 朋之
Tokyo Research Laboratories Kowa Co. Ltd.
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鳥居 功博
Tokyo Research Laboratories Kowa Co. Ltd.
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新井 晃一
Tokyo Research Laboratories Kowa Co. Ltd.
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大口 正夫
Tokyo Research Laboratories Kowa Co. Ltd.
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平田 光輝
Tokyo Research Laboratories Kowa Co. Ltd.
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枝野 敏行
Tokyo Research Laboratories Kowa Co. Ltd.
関連論文
- Purification and Characterization of Endothelin-1 Degradation Activity from Porcine Kidney
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- Syntheses and Biological Activities of Endothelin-1 Analogs
- Inhibition of Endothelin (ET)-1- and ET-2-Induced Vasoconstriction by Anti-ET-1 Monoclonal Antibody
- Phospholipid-Binding Properties of Calphobindin-II(Annexin VI), an Anticoagulant Protein from Human Placenta
- Effects of Calphobindin II (Annexin VI) on procoagulant and Anticoagulant Activities of Cultured Endothelial Cells
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