Inhibitory Effects of Catechol Derivatives on Arachidonic Acid-Induced Aggregation of Rabbit Platelets

概要

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Pyrocatechol and other non-substituted dihydric phenols, which have strong redox power, inhibited arachidonic acid-induced aggregation of rabbit platelets at much lower concentrations than those at which these phenols inhibited stable prostaglandin endoperoxide, U46619-induced aggregation. Among non-substituted dihydric phenols, pyrocatechol was most potent. In order to clarify the physicochemical properties of the phenolic compounds which control the inhibitory potencies of dihydric phenols, we observed the inhibitory effects of 3- and 4-substituents of pyrocatechol on arachidonic acid-induced platelet aggregation. Among seven derivatives tested, the inhibitory effect of 4-C_6H_5-substituent was strongest and 4-COOH-substituent was weakest. Inhibitory effects of the catechol derivatives were well correlated with the quotients of their hydrophobicities and oxidation-reduction potentials. Inhibitory effects of hydroquinone and resorcinol were also on the same correlation line. These results suggest that the inhibitory effects of catechol derivatives and other dihydric phenols are controlled by two physicochemical properties : oxidation-reduction potential and hydrophobicity.
公益社団法人日本薬学会の論文
1991-04-25