Protein Binding of Sulfonylureas. I. Interaction of Some Substituted Benzenesulfonyl Propylureas to Bovine Serum Albumin

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概要

• 論文の詳細を見る

• Binding affinities of five 4-substituted benzenesulfonyl propylureas to bovine serum albumin (BSA) were investigated by equilibrium dialysis method. Those of chlorpropamide (CPU) to BSA was also investigated by dynamic dialysis method using ^<35>S labelled CPU. Results of both methods agreed very well. Binding paramethers of these compounds to BSA were obtained assuming that there were two classes of binding sites. CPU and 4-iodobenzenesulfonyl propylurea were bound to BSA stronger than benzenesulfonyl, p-toluenesulfonyl and 4-aminobenzenesulfonyl propylureas with regard to the primary binding site.

• 公益社団法人日本薬学会の論文
• 1977-12-25

著者

• 亀谷 富士夫

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 亀谷 富士夫

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 須見 泰子

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 須見 泰子

  Faculty Of Pharmaceutical Sciences University Of Tokushima

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• Protein Binding of Sulfonylureas. I. Interaction of Some Substituted Benzenesulfonyl Propylureas to Bovine Serum Albumin
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