Stereocontrolled Synthesis of Exocyclic Olefins Using Arene Tricarbonyl Chromium Complex-Catalyzed Hydrogenation. I. Efficient Synthesis of Carbacyclin and Its Analogs

概要

論文の詳細を見る
An efficient synthesis of carbacyclin and its analogs (2-7) is described in which the stereospecific 1,4-hydrogenation of a 1,3-diene to an internal monoene plays a key role. That is, arene・Cr(CO)_3 complex-catalyzed 1,4-hydrogenation of the dienes 13 and 58,obtainable from the Corey lactone in good yields, under high H_2 pressure afforded the exocyclic olefins 14 and 61 stereospecifically in excellent yields, and these intermediates were converted to therapeutically useful carbacyclin (2) and its analogs 3-7 in a usual way.
社団法人日本薬学会の論文
1991-02-25