Synthesis of Macromolecular Prodrugs of Procaine, Histamine and Isoniazid

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概要

• 論文の詳細を見る

• The attachment of various drugs bearing-NH_2 groups to poly-α, β-aspartic acid as a biodegradable carrier afforded in good yields macromolecular prodrugs which were characterized with respect to composition and drug load by spectroscopic and analytical method. N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) in an aqueous medium peoved to be useful in the attachment reaction. Isoniazid, procaine and histamine were covalently coupled as pendant groups onto poly-α, β-aspartic acid via an amide bond. In principle, controlled release of the aforementioned drugs can be achieved by biodegradation of the polymer or by cleavage of covalently bound polumer-drug conjugates.

• 公益社団法人日本薬学会の論文
• 1989-08-25

著者

• Bajardi Maria

  Department Of Chemistry And Pharmaceutical Technologies University Of Palermo

• GIAMMONA Gaetano

  Department of Chemistry and Pharmaceutical Technologies, University of Palermo

• GIANNOLA Libero

  Department of Chemistry and Pharmaceutical Technologies, University of Palermo

• CARLISI Bianca

  Department of Chemistry and Pharmaceutical Technologies, University of Palermo

• Carlisi Bianca

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

• Giannola Libero

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

• Giammona Gaetano

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

関連論文

• Synthesis of Macromolecular Prodrugs of Procaine, Histamine and Isoniazid
• Synthesis of Polymeric Derivatives of Isoniazid : Characterization and in Vitro Release from a Water-Soluble Adduct with Polysuccinimide

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