Synthesis of Polymeric Derivatives of Isoniazid : Characterization and in Vitro Release from a Water-Soluble Adduct with Polysuccinimide

スポンサーリンク

概要

• 論文の詳細を見る

• Coupling of isoniazid with polysuccinimide afforded a water-insoluble polymeric pro-drug; by reaction with ethanolamine it was chemically transformed in a water-soluble adduct. The in vitro release of isoniazid from the drug-polymer adduct was studied by using an artificial stomach wall lipid membrane. The transfer rate constant from simulated gastric juice to simulated plasma was defined and compared with that of an equivalent dose of pure drug.

• 公益社団法人日本薬学会の論文
• 1989-04-25

著者

• Carlisi Bianca

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

• Giannola Libero

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

• Giammona Gaetano

  Dipartimento Di Chimica E Tecnologie Farmaceutiche Universita Di Palermo

関連論文

• Synthesis of Macromolecular Prodrugs of Procaine, Histamine and Isoniazid
• Synthesis of Polymeric Derivatives of Isoniazid : Characterization and in Vitro Release from a Water-Soluble Adduct with Polysuccinimide

スポンサーリンク