A Novel Heterocyclic Compound. Synthesis and Reactivities of an Oxazolo[3,2-a]thieno[3,2-d]pyrimidine Derivative

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概要

• 論文の詳細を見る

• A practical preparation of 2,3-dihydro-5H-oxazolo[3,2-a]thieno[3,2-d]pyrimidin-5-oen (2) from methyl 3-aminothiophene-2-carboxylate in two steps was developed. The addition reactions of various nucleophiles to 2 were investigated and oxazole-ring-opened compounds were produced (5,6,12,13 and 14). Desulfurization reaction of 2 with Raney Ni gave an oxazolo[3,2-a]pyrimidine derivative (15). It was found that 2 showed potent anti-gastric secretion activity.

• 公益社団法人日本薬学会の論文
• 1989-05-25

著者

• 杉山 充男

  Medicinal Chemistry Research Laboratories

• 坂本 俊明

  Medicinal Chemistry Research Laboratories

• 福見 宏

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 福見 宏

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 坂本 俊明

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 杉山 充男

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

関連論文

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• Condensed Thienopyrimidines. I. : Synthesis and Gastric Antisecretory Activity of 2,3-Dihydro-5H-oxazolothienopyrimidin-5-one Derivatives
• Piperidineacrylate Derivatives as Potential Antiallergy Agents
• Condensed Thienopyrimidines. IV. : Synthesis and Gastric Antisecretory Activity of 2,3-Dihydro-5H-oxazolothienopyrimidine Derivatives
• Total Synthesis of Mimosamycin
• A Novel Heterocyclic Compound. Synthesis and Reactivities of an Oxazolo[3,2-a]thieno[3,2-d]pyrimidine Derivative

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