Colorimetric Determination of Terbutaline Sulfate in Pharmaceutical Preparatinos Using Phenanthro[9,10-d]imidazole-2-N-chloroimide

概要

論文の詳細を見る
A simple and sensitive colorimetric method for the determination of terbutaline sulfate by using phenanthro[9,10-d]imidazole-2-N-chloroimide (PI-NCl) has been developed.Terbutaline slfate reacts with PI-NCl at pH 8 without any oxidant to give an indophenol dye having an absorption maximum at 525nm. A linear calibration plot for terbutaline sulfate was obtained over the concentration range of 0.7-270μg/ml. The method was applied to the analysis of terbutaline sulfate in commercial pharmaceutical preparations. The relative standard deviations were 0.36% (injection, n=5), 0.44% (tablets, n=5), and 0.62% (fine granules, n=5).
社団法人日本薬学会の論文
1989-11-25