Spectroscopic Study of Hydrophobic Interaction of Heterocyclic Amine N-Oxides with Cyclodextrins

概要

論文の詳細を見る
Electronic spectra of aromatic amine N-oxides show a marked blue shift with the change of solvent polarity from aprotic solvents to protic ones. This is very usuful to examine the hydrophobic interaction between the amine N-oxides and cyclodextrins (CyD) in water. Among the various systems studied a typical example is the system of 4-nitroquinoline N-oxide (4NQO) and 2,6-di-O-methyl-β-cyclodextrin in water. A clear red shift of the ultraviolet (UV) spectrum of 4NQO was observed upon inclusion complex formation, indecating directly that the CyD cage environment is much more hydrophobic than in water. Thermodynamic and spectroscopic constants pertinent to those inclusion complex formations were ecaluated and the results are discussed in relation to the complex formation mechanisms.
公益社団法人日本薬学会の論文
1988-10-25