Suppression of Delayed-Type Hypersensitivity in Mice by 12-Tetradecanoylphorbol-13-acetate

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The effect of a potent tumor promoter, 12-tetradecanoylphorbol-13-acetate (TPA), on delayed type hypersensitivity (DTH) to sheep red blood cells (SRBC) in ddy mice was investigated. The mice were immunized with 10^8 SRBC, and footpad reaction (FPR) was measured after challenge with 10^8 SRBC. When 5μg of TPA was administered to the mice 24h before the challenge by painting on the skin. FPR was markedly suppressed. The suppression was greater in the painting of TPA on the footpads of the challanged leg than on the footpad of the other leg. These data suggest that the suppression of FPR involves not only a systemic process, but also a local effect.The application of 4 phorbol related compounds (TPA, phorbol 12,13-didecanoate, 4α-phorbol 12,13-didecanoate and phorbol) showed that the suppressive effect was on DTH virtually paralleled the tumor-promoting activity. Treatments with λ-carrageenan and formaldehyde did not suppress the FPR. These data suggest that the present effect may not be related to the phlogistic effect.
公益社団法人日本薬学会の論文
1986-06-25