Application of the Carbon Dioxide Gas-Sensing Electrode. II. Determination of Chlorzoxazone by Decomposition with Alkali
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概要
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A simple potentiometric method for the determination of chlorzoxazone, based on the use of a carbon dioxide gas-sensing electrode, is described. Details are also given of the operation and handling of the carbon dioxide electrode and the effects of factors which influence the potential. Chlorzoxazone decomposes into aminophenol and sodium carbonate on refluxing with 3N sodium hydroxide. After acidification with pH 4.5 citrate buffer, the carbon dioxide evolved in the decomposition solution was determined. A linear calibration plot was obtained within the concentration range of 3×10^<-4>-5×10^<-3> M drug. The method was applied to the analysis of tablets.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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田上 昇一郎
Faculty Of Pharmaceutical Sciences University Of Toyama
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田上 昇一郎
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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村本 吉弘
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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村本 吉弘
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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