Simultaneous Determination of Acid Dissociation Constants and True Partition Coefficients by Analysis of the Apparent Partition Coefficients. III. The Application of the Hammett Acid Function
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概要
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Equations for the simultaneous determination of acid dissociation constants (pK_a) and true partition coefficients (P) of a very weak base or acid have been derived by applying the Hammett acid functions H_o and H_- and by analyzing the acid function dependence of the apparent partition coefficient (P_a). The equations show that P_a^<-1> is linearly related to h_o (h_o=10^<-H_o>) and h_^<-1>(h_-=10^<-H_->) for a base and an acid, respectively. Some experimental systems for bases have been successfully measured using octanol as an organic solvent phase and suitably diluted H_2SO_4 solution as an aqueous phase, the H_o value being used. The results obtained were reasonably consistent with the literature values. The application of this technique makes it possible to determine log P and pK_a simultaneously, the latter values being smaller than 0 for bases and larger than 14 for acids.
- 公益社団法人日本薬学会の論文
- 1983-04-25
著者
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窪田 種一
Gifu Pharmaceutical University
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加納 健司
Gifu Pharmaceutical University
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花村 治朗
Gifu College of Pharmacy
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小林 恵子
Gifu College of Pharmacy
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花村 治朗
Gifu Pharmaceutical University
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