Significance of Stomach-Emptying-Controlled Rabbits for GI Absorption Studies of Water-Soluble Drugs
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概要
- 論文の詳細を見る
The usefulness of stomach-emptying-(SE-) controlled rabbits for GI absorption studies of relatively water-soluble drugs was investigated, employing aminopyrine and sulfisoxazole as model drugs. When aminopyrine was administered, similar plasma level-time curves were obtained in both SE-controlled and conventionally fasted rabbits. In the case of sulfisoxazole, the time required to reach the peak plasma level was much longer in conventionally fasted rabbits than in the SE-controlled group. It was concluded that use of conventionally fasted rabbits for GI absorption studies should be limited to work on water-soluble drugs.
- 社団法人日本薬学会の論文
- 1980-09-25
著者
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野口 哲男
Formulation Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.
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野口 豪
Formulation Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
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前田 忠男
Formulation Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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野口 豪
Formulation Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.
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前田 忠男
Formulation Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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山平 良也
Formulation Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.
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