Use of Rabbits for GI Drug Absorption Studies : Physiological Study of Stomach-Emptying Controlled Rabbits

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of stomach-emptying control on the physiological state of rabbits was examined. An improved"cangue method"for stomach-emptying control is described and compared with the previously reported"muzzle method."The increment of rabbit body weight indicated that pre-feeding of the special solid diet to rabbits in both methods did not affect their physiological state. Physiological normality of these rabbits was also confirmed in terms of urine pH and packed cell volume. The cangue method was found to be superior to the muzzle method as regards easy operation, the prevention of coprophagy and negligible damage to the stomach during the process of gastric lavage. Analysis of hemocytological and clinico-biochemical data suggested that the physiological state of rabbits is hardly affected by stomach-emptying control using either method.

• 公益社団法人日本薬学会の論文
• 1979-12-25

著者

• 野口 豪

  Formulation Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.

• 山平 良也

  Formulation Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.

• 前田 忠男

  Formulation Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.

• 武仲 宏

  Formulation Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.

• 野口 豪

  Formulation Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.

• 前田 忠男

  Formulation Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 山平 良也

  Formulation Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.

関連論文

• Biopharmaceutical Study of Inclusion Complexes. I. Pharmaceutical Advantages of Cyclodextrin Complexes of Bencyclane Fumarate
• Biopharmaceutical Characteristics of Indomethacin Gel Ointment
• Significance of Stomach-Emptying-Controlled Rabbits for GI Absorption Studies of Water-Soluble Drugs
• Lipid-Containing Oral Dosage Form : Significance of the Intragastric Metabolism of Medium Chain Triglyceride in Relation to the Uniformity of Drug Absorption Rate
• Absorption of Diazepam from a Lipid-Containing Oral Dosage Form
• Use of Rabbits for Absorption Studies on Polymorphs of Chloramphenicol Palmitate
• Use of Rabbits for GI Drug Absorption Studies : Physiological Study of Stomach-Emptying Controlled Rabbits
• Differential Scanning Calorimetry of Chloramphenicol Palmitate and the Phase-Transitional Behavior of Chloramphenicol Palmitate observed during the Preparation of Its Oral Suspension
• Thermal Behavior of the Delta Form of Chloramphenicol Palmitate

スポンサーリンク