The Synthesis of new Derivatives of 1-β-D-Arabinofuranosylcytosine

概要

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In order to obtain 1-β-D-arabinofuranosylcytosine derivatives with better antitumor effect, 12 kinds of saturated fatty acyl groups were introduced at the N^4-position of 1-β-D-arabinofuranosylcytosine. The presence of a great excess of water and about two-fold equivalents of carboxylic anhydride was found to be most desirable for selective N^4-acylation. This simple method of one-step N^4-acylation should be generally applicable to cytosine nucleosides and a variety of carboxylic anhydrides.
公益社団法人日本薬学会の論文
1978-03-25