Conformational Analysis of Prostaglandins. III. Study on Active Sites and Conformation-Action Relationship
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A physicochemical and mathematical model of the mechanism of physiological action was assumed, and the model was applied on prostaglandins. A conformation-action relationship was studied using the model, and high values of correlation coefficients were obtained. Biological activities of prostaglandins on rat uterus, guinea pig ileum, and rabbit jejunum were explained using the model. Active sites of prostaglandins were derived from the mathematical model. They are the oxygen atom bonded to the carbon atom C_1,the oxygen atom bonded to C_9,the oxygen atom bonded to C_<15>, and the carbon atom C_5 or C_<20>.
- 公益社団法人日本薬学会の論文
- 1977-12-25
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