Variability in the Lysolecithin Content of Human Erythrocyte Membranes
スポンサーリンク
概要
- 論文の詳細を見る
It was confirmed that the lysolecithin contents of human erythrocyte membranes (stroma) can be varied remarkably depending on the plasma lysolecithin concentration in vitro and that simultaneously certain changes occur in the morphology of the whole cell as revealed by scanning electron microscopy, and also in the osmotic fragility of the membranes. Incubation of erythrocytes in lysolecithin-rich plasma, prepared by the action of the plasma lecithin-cholesterol acyltransferase or of added phospholipase A of snake venom, resulted in remarkable increase in the lysolecithin content of the erythrocyte membranes and morphological changes in the erythrocytes from normal biconcave discs to crenated or spherical forms. The spherical cells, but not the crenated cells, showed increased osmotic fragility. After washing these lysolecithin-rich erythrocytes with serum albumin solution or with heated normal plasma, the erythrocyte lysolecithin content was restored almost to the normal level whereas the increased osmotic fragility still persisted. Similar washes of the normal erythrocytes with albumin solution gave rise to about 43% decrease in the lysolecithin content, slight morphological change and also slight increase in the osmotic fragility. When these cells were incubated in heated normal plasma, the lysolecithin content was restored to the normal level, and at the same time both the slightly-altered shape and osmotic fragility were restored back to normal. From these experimental findings, probable existence of two kinds of lysolecithin pools in human erythrocyte membranes and their roles in the maintenance of the membrane structure and functions were discussed.
- 1973-01-25
著者
関連論文
- Binding of Calcium and Magnesium Ions to Human Erythrocyte Membranes
- Changes in Shape and Osmotic Resistance of Human Erythrocytes resulted from Changes in the Lysolecithin Content of the Membranes
- Calcium and Magnesium Contents of Mammalian Erythrocyte Membranes
- Abnormal Distribution of Phospholipids in Aorta of the Rabbits with Experimental Atherosclerosis
- Phospholipid Distribution in Erythrocyte and Plasma of the Man, Cow, Pig and Rabbit
- Variability in the Lysolecithin Content of Human Erythrocyte Membranes
- Proton Magnetic Resonance Study of the Interaction of Chlorpromazine Hydrochloride with Lecithin Vesicles
- Synthesis of Spiro [4-hydroxycyclohexane-1,4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline]