Inhibition of the Synthesis of Macromolecules in Escherichia coli by Nitrofuran Derivatives. II. Various Nitrofuran Derivatives

概要

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Using 26 nitrofuran derivatives with various chemical structures, the inhibition of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and protein syntheses was examined in intact cell and protoplast lysate systems of Escherichia coli JG181. All the derivatives active against the strain inhibited DNA synthesis in the both systems. However, RNA and protein syntheses were inhibited by some of them in intact cell system and by all but one in protoplast lysate system. The derivatives inactive against the strain but active against staphylococci showed no inhibition in intact cell system although one of them inhibited DNA and RNA syntheses in protoplast lysate system. The derivatives inactive against all bacteria tested did not show inhibition at all in the both systems. Among the syntheses tested, the most inhibited was DNA synthesis and the degree of inhibition in intact cell system was closely correlated to antibacterial activity. The results indicate that the inhibition of DNA synthesis may be a common mechanism of antibacterial action of nitrofuran derivatives.
社団法人日本薬学会の論文
1973-01-25