Studies on Digitalis Glycosides. XXVI. Gitoxin Acetates. (1). Deacetylation of Pentaacetylgitoxin
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概要
- 論文の詳細を見る
Hydrolysis of pentaacetylgitoxin (I) with diastase gave selectively 3', 3'', 3''', 16-tetraacetylgitoxin (IIa) as a main product. When IIa was treated with potassium hydrogen carbonate, acetyl groups were successively eliminated in the order of those at C-3''', -16,-3'' or -3' positions to afford 3', 3'', 16-triacetylgitoxin (IIc), 3', 3''-diacetylgitoxin (IId), 3'-monoacetylgitoxin (acetylgitoxin-γ, IIe) and gitoxin (IIf). These partial acetates did not agree with those obtained in acetylation of gitoxin (IIf), in which acetyl groups were introduced in the order at C-4''', -16,-3''' or -3' positions. The partial acetates obtained by the former method (deacetylation) were thought to be more essential for the study of metabolism of I than those prepared by the latter method (acetylation).
- 社団法人日本薬学会の論文
- 1968-06-25
著者
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佐藤 大助
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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森田 淳子
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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森田 淳子
Shionogi Research Laboratory Shionogi & Co. Ltd.
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佐藤 大助
Shionogi Research Laboratory Shionogi & Co. Ltd.
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