Studies on Digitalis Glycosides. XIX. Microbiological Transformation of Digitoxigenin Derivatives by Absidia orchidis
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概要
- 論文の詳細を見る
Through the microbiological transformation of 3β, 14,21-trihydroxy-14β-pregnan-20-one (III) and 4,5-dehydrodigitoxigenone (IV) by Absidia orchidis, several kinds of products were isolated, and the structure and configuration of three hydroxylated products, one from III and two from IV, were clarified ; 1β, 3β, 14,21-tetrahydroxy-14β-pregnan-20-one (V), 7β, 12β-dihydroxy-4,5-dehydrodigitoxigenone (VIII), and 7β-hydroxy-4,5-dehydrodigitoxigenone (IX). Based on these experimental results, the relationships between the structure of substrate and the positions to be hydroxylated in the microbiological transformation of cardiac aglycone derivatives by A.orchidis were discussed.
- 社団法人日本薬学会の論文
- 1964-10-25
著者
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佐藤 大助
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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佐藤 大助
Shionogi Research Laboratory Shionogi & Co. Ltd.
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奥村 保
Shionogi Research Laboratory Shionogi & Co. Ltd.
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野崎 義雄
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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野崎 義雄
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
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- Studies on Digitalis Glycosides. XXI. 14,15-Epoxy and 15-Oxo Derivatives of 3β-Acetoxy-5β, 17α-cardenolide
- Studies on Digitalis Glycosides. XIX. Microbiological Transformation of Digitoxigenin Derivatives by Absidia orchidis
- Studies on Digitalis Glycosides. The Configuration of Digiprogenin
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- Studies on Digitalis Glycosides Structure of Purpnigenin and Purprogenin
- Studies on Digitalis Glycosides. Acetylgitoxin-α from Gitoxin
- Studies on Digitalis Glycosides. VII. Gitoroside, : Digitalonin, and Gitoxin Pentaacetate.
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