Studies on Glutamic Oxalacetic Transaminase in the Rat. III. Hormonal Control of Isoenzyme Levels in Liver by the Pituitary-Adrenal System
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概要
- 論文の詳細を見る
Glutamic oxalacetic transaminase (GOT) is one of main transaminase in liver. This enzyme has not been induced so active by glucocorticoids as other transaminases. However, the presence of isoenzymes and their characteristics were investigated and the same hormonal sensitivity to glucocorticoids was observed in the enzyme localized in the soluble fraction (s-GOT). In our present paper, the regulation by adrenal hormones was proven to be exist not only in s-GOT but also in the mitochondrial enzyme (m-GOT) which is major component in rat liver. Furthermore, it is suggested that catecholamines would play a role on defining of isoenzyme level in liver and leakage of enzyme from tissue.
- 公益社団法人日本薬学会の論文
- 1968-10-25
著者
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米谷 行男
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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馬場 良子
Shionogi Research Laboratory Shionogi & Co. Ltd.
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米谷 行男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小川 保直
Shionogi Research Laboratory Shionogi And Co. Ltd.
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