Studies on Isothiazoles. II. Nitration of 3-Phenylisothiazoles
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概要
- 論文の詳細を見る
Nitration of 4-substituted-3-phenyliosthiazoles (I, II, III, and IV) with fuming nitric acid and sulfuric acid yielded exclusively the corresponding 3-m-nitrophenyl derivatives (VI, VII, VIII and IX), while nitration of 3-phenylisothiazole (V) gave 3-p-nitrophenylisothiazole (Xa) and 3-m-nitrophenylisothiazole (Xb). Reduction of 5-methyl-3-m-nitrophenylisothiazole-4-carboxylic acid (IX) afforded the corresponding amino derivative (VII), which was diazotized and subjected to the Sandmeyer Reaction to give the corrsponding 3-m-chlorophenyl (XIV) and 3-m-bromophenyl (XV) derivatives. Preparation of the 3-m-methoxyphenyl derivative (XVII) was also described.
- 社団法人日本薬学会の論文
- 1968-01-25
著者
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中川 晋
Bristol-banyu Research Institute Ltd.
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内藤 隆之
Bristol-myers Squibb Research Institute Ltd. Tokyo Research Center
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内藤 隆之
Bristol-banyu Research Institute Ltd.
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高橋 清
Bristol-Banyu Research Institute, Ltd.
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高橋 清
Bristol-banyu Research Institute Ltd.
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