Studies on Carcinostatic Substances. XXXIX. Antitumor Effect of Derivatives of Nitrogen Mustard containing only one 2-Chloroethyl Group.
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Twenty-three derivatives of N-alkyl-N-2-chloroethyl-N-ω-chloroalkylamine were prepared. It was proved that these compounds are completely monofunctional biological alkylating agents from the estimation of reaction velocity in vitro, but neverthless they exhibit a strong antitumor effect on rats bearing Yoshida sarcoma. The fact is very interesting from the point of the mode of action of nitrogen mustards.
- 公益社団法人日本薬学会の論文
- 1962-05-25
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関連論文
- Studies on Carcinostatic Substances. XXXVII. Preparation of Derivatives of Nitrogen Mustard having Metal Chelate-forming Activity.
- Studies on Carcinostatic Substances. XXXIX. Antitumor Effect of Derivatives of Nitrogen Mustard containing only one 2-Chloroethyl Group.
- Studies on Carcinostatic Substances. XXXVIII. Chemical and Antitumor Properties of Monofunctional Derivatives of Nitrogen Mustard.