Chemicopharmacological Studies on Antispasmodic Action. XVII. Effect of Hydrogen Ion Concentration upon Atropine- and Papaverine-like Actions
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(1) The competitive inhibitory action of atropine to acetylcholine was augmented at a lower pH. The synergistic effect of atropine and hydrogen ion was between addition and potentiation. On the contrary, 1,1-diphenyl-3-piperidino-1-butanol was proved to have an additive effect to atropine in the range of concentration where it has only atropine-like action. A discussion on the curious behavior of H^+ on ACh receptor is presented. (2) The atropine-like activity of 1,1-diphenyl-3-piperidino-1-butanol was subjected to the same potentiation with H^+ as atropine and the papaverine-like activity of the same compound was hardly affected by H^+ within the range of pH 5.6〜7.4. It was concluded that a specific receptor for papaverine-like action has a strong acidity or that the presence of the receptor must be denied.
- 公益社団法人日本薬学会の論文
- 1959-10-20
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関連論文
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- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. IV. Relationship between Anticholinergic and Anticholinesterase Activities of Organophosphoryl Choline Derivatives based on their Chemical Structure
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. III. The Site of Action of Organophosphate Group on the Acetylcholine Receptor Surface.
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. II. The Mode of Action of Parathion on an Acetylcholine Receptor.
- Chemicopharmacological Studies on Antispasmodic Action. XVII. Effect of Hydrogen Ion Concentration upon Atropine- and Papaverine-like Actions
- Chemicopharmacological Studies on Antispasmodic Action. XVI. Effect of Hydrogen Ion Concentration on Acetylcholine Receptor