Chemicopharmacological Studies on Antispasmodic Action. XVI. Effect of Hydrogen Ion Concentration on Acetylcholine Receptor
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(1) A modified salt solution, which does not contain sodium hydrogen carbonate, was used in this experiment to study the effect of pH on the small intestines of mice. (2) The dose-contraction curve of N-butyltrimethylammonium bromide obeyed Clark's equation and the slope was 1.2. The curve was inhibited competitively in pH range between 6.0 and 5.5. (3) From the interaction between N-butyltrimethylammonium bromide and H^+, the pKa of the anionic site of ACh-receptor was estimated as 6.15 and as 6.16 in the case of ACh and H^+. These values are very close to pKa 6.2 of the anionic site of ACh-esterase, estimated by Wilson and Bergmann.
- 公益社団法人日本薬学会の論文
- 1959-10-20
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関連論文
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. I. Antagonism to Acetylcholine of Organophosphorous Compounds.
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. V. The Comparison of the Active Sites of Acetylcholine Receptor and Cholinesterase Surface
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. IV. Relationship between Anticholinergic and Anticholinesterase Activities of Organophosphoryl Choline Derivatives based on their Chemical Structure
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. III. The Site of Action of Organophosphate Group on the Acetylcholine Receptor Surface.
- Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. II. The Mode of Action of Parathion on an Acetylcholine Receptor.
- Chemicopharmacological Studies on Antispasmodic Action. XVII. Effect of Hydrogen Ion Concentration upon Atropine- and Papaverine-like Actions
- Chemicopharmacological Studies on Antispasmodic Action. XVI. Effect of Hydrogen Ion Concentration on Acetylcholine Receptor