Synthesis of Related Compounds of Thiosemicarbazide. III s-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives. (2).
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2-R-5-R'-s-Triazolo[3,4-b]-1,3,4-thiadiazoles (V) were synthesized starting with 2-hydrazino-5-R-1,3,4-thiadiazole (III : R=CH_3,C_2H_5,n-C_3H_7,iso-C_4H_9,C_6H_5), reacting them with either ethyl orthoacylate or ethyl acylimidate (R'=H, CH_3,C_2H_5,n-C_3H_7,n-C_4H_9) to form ethyl N'-(5-R-1,3,4-thiadiazol-2-yl) hydrazonoacylate (IV), and cyclization with acetic acid. Treatment of (III) by heating with 80% formic acid produced 2-R-s-triazolo[3,4-b]-1,3,4-thiadiazole (V, R'=H).
- 公益社団法人日本薬学会の論文
- 1957-10-20
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関連論文
- Synthesis of Related Compounds of Thiosemicarbazide. III s-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives. (2).
- Synthesis of Related Compounds of Thiosemi-carbazide. IV. 1-(1,3,4-Thiadiazol-2-yl)-2-pyrazolin-5-one and Tetrazolo [4,5-a]-1,3,4-thiadiazole Derivatives.