フラン誘導体の合成(第14報)β-(5-ニトロ-2-フリル)-α-メチル-, β-(5-ニトロ-2-フリル)-α-エチル-, β-(5-ニトロ-2-フリル)-α-ブロモアクロレイン誘導体の合成について
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概要
- 論文の詳細を見る
β-(5-Nitro-2-furyl)-α-methylacrolein and β-(5-nitro-2-furyl)-α-ethylacrolein were prepared by the condensation of 2-(5-nitro) furfural with propionaldehyde and butyraldehyde, respectively, in the presence of piperidinium acetate as a catalyst. Preparation of β-(5-nitro-2-furyl)-α-bromoacrolein was accomplished by bromination in the usual manner. These new compounds were used as an antibacterial group in the preparation of Schiff bases with semicarbazides, hydrazides, and amines, and then antibacterial screening of these bases was carried out. From the screening results, β-(5-nitro-2-furyl)-α-methylacrolein semicarbazone, β-(5-nitro-2-furyl)-α-methylacrolein oxime, and 1-[β-(5-nitro-2-furyl)-α-bromoacrylidene]-2-isonicotinylhydrazine were found to exert great activity against tubercle bacilli.
- 公益社団法人日本薬学会の論文
- 1955-12-20
著者
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星田 晴彦
Pharmaceutical Institute Medical Faculty University Of Kyushu
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西海枝 東雄
Pharmaceutical Institute Medical Faculty University Of Kyushu
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小川 晴
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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古川 厳
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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古川 厳
Pharmaceutical Institute Medical Faculty University Of Kyushu
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- フラン誘導体の合成化学的研究(第14報)2-(5-ニトロ)-フリルアクロレン及び2-(5-ニトロ)-フラアルデヒドとヒドラジット類の縮合について
- フラン誘導体の合成(第14報)β-(5-ニトロ-2-フリル)-α-メチル-, β-(5-ニトロ-2-フリル)-α-エチル-, β-(5-ニトロ-2-フリル)-α-ブロモアクロレイン誘導体の合成について
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