A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors

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概要

• 論文の詳細を見る

• A simplified approach to the synthesis of 2-polyamine linked-monoindolylmaleimides has been achieved, leading to a new series of trypanothione reductase inhibitors. The conditions of access to N, 2-bis(polyamine)-3-monoindolylmaleimides and N, N'-bis(monoindolylmaleimide) polyamines are described. Measured inhibitory activities towards trypanothione reductase from Tryanosoma cruzi show the importance of both aromatic moieties and polyamine chains for trypanothione reductase recognition.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• Davioud-charvet Elisabeth

  Institut De Biologie De Lille - Institut Pasteur De Lille - Ura Cnrs 1309

• SERGHERAERT Christian

  Institut de Biologie et Institut Pasteur de Lille, UMR CNRS 8525, Universite de Lille 2

• Salmon Laurence

  Institut De Biologie De Lille - Institut Pasteur De Lille - Ura Cnrs 1309

• Maes Louis

  Janssen Research Foundation

• LANDRY Valerie

  Institut de Biologie de Lille - Institut Pasteur de Lille - URA CNRS 1309

• MELNYK Oleg

  Institut de Biologie de Lille - Institut Pasteur de Lille - URA CNRS 1309

• Sergheraert Christian

  Institut De Biologie De Lille - Institut Pasteur De Lille - Ura Cnrs 1309

関連論文

• Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity
• "One-Pot"Synthesis and Antimalarial Activity of Formamidine Derivatives of 4-Anilinoquinoline
• A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors
• Identification of Inhibitors of an 80 kDa Protease from Trypanosoma cruzi through the Screening of a Combinatorial Peptide Library
• Compared Reactivities of Trypanothione and Glutathione in Conjugation Reactions

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