Compared Reactivities of Trypanothione and Glutathione in Conjugation Reactions

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概要

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• In order to compare the non-enzymatic capacities of the xenobiotic conjugation of trypanothione (a spermidine-glutathione conjugate unique to kinetoplastidae) and glutathione, the reactivity of their respective thiols was investigated. The acido-basic properties of both compounds and their nucleophilicity toward Elliman's reagent and 1-chloro-2,4-dinitrobenzene were studied. Our results show that although glutathione is a better nucleophile than trypanothione, the latter is more reactive because it is more ionized in a large pH range. This pH range likely includes the pH to which such conjugation reactions are expected to happen in vivo. Thus, the better conjugation capacity of trypanothione could make it the cornerstone for the xenobiotic detoxication of trypanosomatidae.

• 公益社団法人日本薬学会の論文
• 1994-12-15

著者

• Sergheraert Christian

  Institut Pasteur-ura Cnrs 1309

• Sergheraert Christian

  Institut De Biologie De Lille - Institut Pasteur De Lille - Ura Cnrs 1309

• MOUTIEZ Mireille

  Institut Pasteur-URA CNRS 1309

• MEZIANE-CHERIF Djalal

  Institut Pasteur-URA CNRS 1309

• AUMERCIER Marc

  Institut Pasteur-URA CNRS 1309

• TARTAR Andre

  Institut Pasteur-URA CNRS 1309

関連論文

• Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity
• "One-Pot"Synthesis and Antimalarial Activity of Formamidine Derivatives of 4-Anilinoquinoline
• A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors
• Identification of Inhibitors of an 80 kDa Protease from Trypanosoma cruzi through the Screening of a Combinatorial Peptide Library
• Compared Reactivities of Trypanothione and Glutathione in Conjugation Reactions

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