Convenient Preparation of Enantiopure Atenolol by Means of Preferential Crystallization

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概要

• 論文の詳細を見る

• (R)- or (S)-Atenolol (1) in enantiopure form was prepared in an extremely simple way. Atenolol of ca. 95% ee was prepared in one-pot from p-hydroxyphenylacetamide (2) and (R)- or (S)-epichlorohydrin (3). Then, preferential crystallization of the Bronsted's acid salts of the resulting atenolol improved the enantiomeric purity up to 99.8% ee.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• Otera J

  Department Of Applied Chemistry Okayama University Of Science

• Otera Junzo

  Department Of Applied Chemistry Faculty Of Engineering Okayama University Of Science

• Yoshimoto H

  Research Laboratories Of Daiso Co. Ltd.

• KITAORI Kazuhiro

  Research Laboratories of Daiso Co., Ltd.,

• TAKEHIRA Yoshikazu

  Research Laboratories of Daiso Co., Ltd.,

• FURUKAWA Yoshiro

  Research Laboratories of Daiso Co., Ltd.,

• YOSHIMOTO Hiroshi

  Research Laboratories of Daiso Co., Ltd.,

• Kitaori Kazuhiro

  Research Laboratories Of Daiso Co. Ltd.

• Furukawa Y

  Nagoya City Univ. Nagoya Jpn

• Takehira Yoshikazu

  Research Laboratories Of Daiso Co. Ltd.

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