A Pratical Synthesis of Optically Active Atenolol from Chiral Epichlorohydrin

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概要

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• The synthesis of (R)- and (S)-atenolol (1) was achieved in two steps starting from p-hydroxyphenylacetamide (2). Both enantiomers of the glycidyl ether 4 were synthesized from 2 and (R)- and (S)-epichlorohydrin (3) using an alkali metal hydroxide and/or BTA (benzyltrimethylammonium chloride), respectively. Subsequent treatment of 4 with isopropylamine afforded atenolol (1) with excellent enantiomeric excess (>98% ee).

• 公益社団法人日本薬学会の論文
• 1997-02-15

著者

• Otera J

  Department Of Applied Chemistry Okayama University Of Science

• Otera Junzo

  Department Of Applied Chemistry Faculty Of Engineering Okayama University Of Science

• Yoshimoto H

  Research Laboratories Of Daiso Co. Ltd.

• KITAORI Kazuhiro

  Research Laboratories of Daiso Co., Ltd.,

• TAKEHIRA Yoshikazu

  Research Laboratories of Daiso Co., Ltd.,

• FURUKAWA Yoshiro

  Research Laboratories of Daiso Co., Ltd.,

• YOSHIMOTO Hiroshi

  Research Laboratories of Daiso Co., Ltd.,

• Kitaori Kazuhiro

  Research Laboratories Of Daiso Co. Ltd.

• Furukawa Y

  Nagoya City Univ. Nagoya Jpn

• Takehira Yoshikazu

  Research Laboratories Of Daiso Co. Ltd.

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