Facile and Efficienct Preparation of a C-1 Side Chain Equivalent of Zaragozic Acid C
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概要
- 論文の詳細を見る
An optically pure C-1 side chain equivalent of zaragozic acid C, (4R, 5R)-4-benzyloxy-5-methyl-6-phenyl-1-hexyne, has been synthesized in ten steps from (E)-4-phenyl-2-buten-1-ol with an overall yield of 50%, involving a Sharpless asymmetric epoxidation as a key step, followed by regio- and stereocontrolled ring-opening of the epoxide with the trimethylaluminum/n-butyllithium system.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
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SATO Hiroki
Graduate School of Science and Engineering, Department of Communications and Integrated Systems, Tok
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Hashimoto Shun-ichi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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KITAGUCHI Jun-ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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NAKAMURA Sei-ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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中村 精一
Faculty Of Pharmaceutical Sciences Hokkaido University
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Sato Hiroki
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kitaguchi J
Hokkaido Univ. Sapporo Jpn
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Sato Hiroki
Graduate School Of Asian And African Area Studies Kyoto University
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