Interactions of Cyclodextrins with DPPC Liposomes. Differential Scanning Calorimetry Studies

概要

論文の詳細を見る
The interaction of cyclodextrins (CDs) with dipalmitoylphosphatidylcholine (DPPC) liposomes had been studied using differential scanning calorimetry (DSC). The phase transition temperature and the enthalpy change due to the gel-to-liquid crystalline phase transition of the liposomes were measured in the presence of α-CD, β-CD, γ-CD, heptakis (2,6-di-O-methyl)-β-CD (DOM-β-CD), heptakis (2,3,6-tri-O-methyl)-β-CD (TOM-β-CD) and 2-hydroxylpropyl β-CD, respectively. The effects on the change of enthalpy of the transition and transition temperature were remarkable in the order of DOM-β-CD>α-CD>TOM-β-CD. The residual CDs caused scarcely detectable changes in the enthalpy changes and the transition temperatures.In order to clarify the DSC curves in the presence of the CDs mentioned above, the type of interactions which occurred between CDs and DPPC liposomes were studied. Consequently, it was found that DOM-β-CD forms a soluble complex and α-CD forms an insoluble complex with DPPC liposomes, whereas only a slight amount of TOM-β-CD was suggested to penetrate the matrix of the liposomes.
公益社団法人日本薬学会の論文
1998-01-15