Unusual Behavior of Ion Transport Mediated by Polyene Antibiotics. Activation Energies for the Exchange of Na^+ Ions through Liposomal Membranes Studied by ^<23>Na-NMR Spectroscopy

スポンサーリンク

概要

• 論文の詳細を見る

• ^<23>Na-NMR spectroscopy has been applied to study the transport of Na^+ ions across unilamellar vesicle membranes mediated by ionophores. The ionophores used were amphotericin B and nystatin. Also, monensin, lasalocid A and gramicidin D were included for the sake of comparison since the transport processes of these ionophores are well characterized as carrier-, and carrier- channel-types, respectively. The ^<23>Na-NMR techniques employed were 2D-EXSY (exchange spectroscopy) and the 1D time-course monitoring techniques, and the measurement exchange rates. These techniques were also applied at different temperatures, and the activation parameters were determined for the ionophore-mediated Na^+ exchange. These activation parameters disclosed an unusual behavior of amphotericin B and nystatin. That is, cation transport through the membrane is decreased on increasing the temperature of measurement, resulting in negative values for the apparent enthalpy of activation. Such unusual behavior is related to the fluidity of the model membrane and to intermolecular interactions in the membrane.

• 公益社団法人日本薬学会の論文
• 1997-03-15

著者

• Kimura Atsuomi

  Faculty Of Pharmaceutical Sciences Osaka University

• Fujiwara H

  Osaka Univ. Suita Jpn

• Fujiwara Hideaki

  Faculty Of Pharmaceutical Sciences Osaka University

• Fujiwara Hideaki

  Faculty Of Medicine Osaka University

• KUNI Naohito

  Faculty of Pharmaceutical Sciences, Osaka University

• Kuni Naohito

  Faculty Of Pharmaceutical Sciences Osaka University

関連論文

• Thermochemical Aspects of Partition. A Study on The Novel Hydrophobic Parameters of Multiply-Substituted Benzoic Acids
• Metabolism of an ionic contrast medium and the related agents
• The Energy Aspects of Oil/Water Partition. Proposition of Novel Hydrophobic Parameters for the Treatment of Quantitative Structure-Activity Relationships
• Unusual Behavior of Ion Transport Mediated by Polyene Antibiotics. Activation Energies for the Exchange of Na^+ Ions through Liposomal Membranes Studied by ^Na-NMR Spectroscopy
• Structural Effects in NMR Spectroscopy of Vinylic Compound 1. Investigation of Intramolecular Specific Interactions C-H…N in Hetaryl Vinyl Ethers by ^1H, ^C, ^N, and ^O NMR Spectroscopies and Quantum-Chemical Calculations
• The solution chemistry of organotin compounds. III. A thermodynamic study of the molecular interaction of Me2SnCl2 with Lewis bases by means of nuclear magnetic resonance spectroscopy.
• Development and applications for the simulater of intermolecular potentials. II. Hydration effects on the conformation of tyramine.
• Entropy changes in the inclusion complex formation of .ALPHA.-cyclodextrin with alcohols as studied by the titration calorimetry.
• NMR study of molecules in anisotropic systems. II. 1a,2a,3e,4e,5e,6e- and 1e,2e,3e,4e,5e,6e-hexachlorocyclohexanes dissolved in nematic liquid crystals.
• Solution structure and preferred orientation of 3,7-dichloro-10H-phenothiazine dissolved in nematic liquid crystal.
• The solution chemistry of organotin compounds. I. A 1H NMR study of the complex formation between methyltin trichloride and 4-substituted pyridines.
• The Energy Aspect of Oil/Water Partition and Its Application to the Analysis of Quantitative Structure-Activity Relationships. Aliphatic Alcohols in the Liposome/Water Partition System.
• Association between polar molecules. III. 1H and 13C NMR studies on the dipole association of acetonitrile derivatives with tetramethylurea and dibutyl sulfoxide in nonpolar solvents.
• Thermodynamic properties of solution of nonspherical molecules determined from gas-liquid chromatography and calculated by the scaled particle theory using the Kihara potential.
• The solvation effect on the reactions in solution. I The solvation model for the interpretation of entropy changes in the complex formation of dichlorodimethylstannane with pyridine.
• The entropy of solution of alkanes measured by gas-liquid chromatography and interpreted by means of scaled particle theory.

もっと見る 閉じる

スポンサーリンク